Fish Oil

The "hallmark" laboratory finding associated with SSADH deficiency is elevated levels of GHB in the urine (i.e., 4-hydroxybutyric or gamma-hydroxybutyric aciduria), the liquid ... (more...)

... Dehydrogenase Deficiency? ... to the enzyme deficiency in SSADH patients, an unusual compound accumulates in the body, namely 4-hydroxybutyric acid (or gammahydroxybutyric acid; GHB). (more...)

In the course of our investigations into the human genetic disease, we noted many similarities between the symptoms of SSADH deficiency and GHB drug abuse," said Gibson. (more...)

... changes including regulation of cell division and differentiation, thus, down-regulation of this pathway may occur during the presence of too much GHB as found in SSADH deficiency. ... (more...)

... that elevate cAMP, such as forskolin and vinpocetine, may increase GHB synthesis and release. People with the disorder known as succinic semialdehyde dehydrogenase deficiency, also ... (more...)

... of SSADH, transamination of ?-aminobutyric acid (GABA) to succinic semialdehyde is followed by reduction to 4-hydroxybutyric acid [?-hydroxybutyrate (GHB)]. SSADH deficiency ... (more...)

About half of the SSADH deficiency patients suffer from seizures. GHB, an addictive drug of abuse, has a wide range of applications ... (more...)

Alcohol and Alcoholism Advance Access originally published online on August 1, 2007 Alcohol and Alcoholism 2007 42(5):506; doi:10.1093/alcalc/agm058 (more...)

... compound has been made even more evident by the recent description of an apparent inborn error of GHB metabolism due to a deficiency in ... (more...)

The "hallmark" laboratory finding associated with SSADH deficiency is elevated levels of GHB in the urine (i.e., 4-hydroxybutyric or gamma-hydroxybutyric aciduria), the liquid ... (more...)